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Anti-SMURF1 Antibody Picoband®

Boster Bio Anti-SMURF1 Antibody Picoband® catalog # PB9892. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

E3 ubiquitin-protein ligase SMURF1 is an enzyme that in humans is encoded by the SMURF1 gene. It is mapped to 7q22.1. This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.

Synonyms

E3 ubiquitin-protein ligase SMURF1; hSMURF1;6.3.2.-; SMAD ubiquitination regulatory factor 1; SMAD-specific E3 ubiquitin-protein ligase 1; SMURF1; KIAA1625

Gene Name

SMURF1

Gene ID

57154

UniProt

Q9HCE7

Host

Rabbit

Reactivity

Human, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human SMURF1, identical to the related mouse sequence.

Clonality

Polyclonal

Tissue Specificity

Expressed in melanocytes (PubMed:23999003) . .

Applications

Flow Cytometry, IF, IHC, ICC, WB

Field of Research

Cell Biology, Proteasome / Ubiquitin, Proteolysis/Ubiquitin, Ubiquitin E3 Enzymes

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Plays a role in dendrite formation by melanocytes (PubMed:23999003) . .

References & Citations

1. Entrez Gene: SMURF1 SMAD specific E3 ubiquitin protein ligase 1. 2. Yamaguchi K, Ohara O, Ando A, Nagase T (Apr 2008) . Smurf1 ly targets hPEM-2, a GEF for Cdc42, via a novel combination of protein interaction modules in the ubiquitin-proteasome pathway. Biol. Chem. 389 (4) : 405–13. 3. Zhu H, Kavsak P, Abdollah S, Wrana JL, Thomsen GH (Sep 1999) . A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature 400 (6745) : 687–93.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

86114 MW

Observed Molecular Weight

86 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

E3 ubiquitin-protein ligase SMURF1

Subcellular Location

Cytoplasm . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side .

Protein Name

E3 ubiquitin-protein ligase SMURF1

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2mg Na2HPO4, 0.05 mg NaN3.

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