Anti-SFRP4 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. It is mapped to 7p14.1. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression. And SFRP4 is a hub gene in a Type 2 Diabetes-associated gene coexpression module in human islets, and reduces glucose-induced insulin secretion through decreased β-cell exocytosis.
Synonyms
Secreted frizzled-related protein 4; sFRP-4; Frizzled protein, human endometrium; FrpHE; SFRP4; FRPHE
Gene Name
SFRP4
Gene ID
6424
UniProt
Q6FHJ7
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E. coli-derived human SFRP4 recombinant protein (Position: A22-K303) . Human SFRP4 shares 96.8% and 96.1% amino acid (aa) sequence identity with mouse and rat SFRP4, respectively.
Clonality
Polyclonal
Tissue Specificity
Expressed in mesenchymal cells. Highly expressed in the stroma of proliferative endometrium. Expressed in cardiomyocytes. Shows moderate to strong expression in ovarian tumors with expression increasing as the tumor stage increases. In ovarian tumors, expression levels are inversely correlated with expression of CTNNB1 (at protein level) . .
Applications
Flow Cytometry
Field of Research
Secreted, Signaling Pathways, Stem Cells
Purification
Immunogen affinity purified.
Form
Liquid
Function
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity) . Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake. .
References & Citations
1. Entrez Gene: SFRP4 secreted frizzled-related protein 4. 2. Horvath LG, Lelliott JE, Kench JG et al. (2007) . Secreted frizzled-related protein 4 inhibits proliferation and metastatic potential in prostate cancer.. Prostate 67 (10) : 1081–90.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
39827 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Secreted frizzled-related protein 4
Subcellular Location
Secreted . Cytoplasmic in ovarian tumor cells.
Protein Name
Secreted frizzled-related protein 4
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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