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Anti-Ribonuclease Inhibitor/RNH1 Antibody Picoband® Fluoro647 Conjugated

Selected Variant

PB9885-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

Ribonuclease inhibitor is an enzyme that in humans is encoded by the RNH1 gene. Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular Rnases. In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin. Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.

Synonyms

Ribonuclease inhibitor; Placental ribonuclease inhibitor; Placental RNase inhibitor; Ribonuclease/angiogenin inhibitor 1; RAI; RNH1; PRI, RNH

Gene Name

RNH1

Gene ID

6050

UniProt

P13489

Host

Rabbit

Reactivity

Human, Monkey, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human RNH1, different from the related mouse sequence by five amino acids, and from the related rat sequence by four amino acids.

Clonality

Polyclonal

Tissue Specificity

Widely expressed; high expression found in skeletal muscle. .

Applications

Flow Cytometry

Field of Research

Angiogenesis, Cardiovascular, DNA/RNA, Epigenetics and Nuclear Signaling, RNA Processing

Purification

Immunogen affinity purified.

Form

Liquid

Function

Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis. .

References & Citations

1. Entrez Gene: RNH1 ribonuclease/angiogenin inhibitor 1. 2. Weremowicz S, Fox EA, Morton CC, Vallee BL (1991) . The placental ribonuclease inhibitor (RNH) gene is located on chromosome subband 11p15.5.. Genomics 8 (4) : 717–21. 3. Zneimer SM, Crawford D, Schneider NR, Beutler B (1991) . Mapping of the human ribonuclease inhibitor gene (RNH) to chromosome 11p15 by in situ hybridization.. Genomics 8 (1) : 175–8.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

49973 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Ribonuclease inhibitor

Subcellular Location

Cytoplasm.

Protein Name

Ribonuclease inhibitor

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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