Anti-NAP2/PPBP Antibody Picoband® Fluoro488 Conjugated

Chemokine (C-X-C motif) ligand 7  (CXCL7), also known as NAP2 or Pro-Platelet basic protein  (PPBP), is a human  gene. The protein encoded by this gene is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. Furthermore, the protein is an antimicrobial protein with bactericidal and antifungal activity.

Platelet basic protein; PBP; C-X-C motif chemokine 7; Leukocyte-derived growth factor; LDGF; Macrophage-derived growth factor; MDGF; Small-inducible cytokine B7; Connective tissue-activating peptide III; CTAP-III; LA-PF4; Low-affinity platelet factor IV; TC-2; Connective tissue-activating peptide III (1-81) ; CTAP-III (1-81) ; Beta-thromboglobulin; Beta-TG; Neutrophil-activating peptide 2 (74) ; NAP-2 (74) ; Neutrophil-activating peptide 2 (73) ; NAP-2 (73) ; Neutrophil-activating peptide 2; NAP-2; TC-1; Neutrophil-activating peptide 2 (1-66) ; NAP-2 (1-66) ; Neutrophil-activating peptide 2 (1-63) ; NAP-2 (1-63) ; PPBP; CTAP3, CXCL7, SCYB7, TGB1, THBGB1

LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2 (73), NAP-2 (74), NAP-2 (1-66), and most potent NAP-2 (1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III (1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation. .

1. Entrez Gene: PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) . 2. Hristov M, Zernecke A, Bidzhekov K; et al. (March 2007) . Importance of CXC chemokine receptor 2 in the homing of human peripheral blood endothelial progenitor cells to sites of arterial injury.Circ. Res. 100 (4) : 590–7. 3. Majumdar S, Gonder D, Koutsis B, Poncz M (1991) . Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4. J Biol Chem 266 (9) : 5785–9.