Anti-FGF23 Antibody Picoband® Fluoro488 Conjugated

Fibroblast growth factor 23?or?FGF23?is a?protein?that in humans is encoded by the?FGF23?gene. This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR) . Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC) .

E. coli-derived mouse FGF23 recombinant protein (Position: R48-V251) . Mouse FGF23 shares 71.1% and 94.6% amino acid (aa) sequence identity with human and rat FGF23, respectively.

Cancer, Cytoskeleton/ECM, Developmental Biology, Extracellular Matrix, Growth Factors, Growth Factors/Hormones, Lineage Markers, Lineage Specification, Signal Transduction, Stem Cells, Structures

Regulator of phosphate homeostasis (By similarity) . Inhibits renal tubular phosphate transport by reducing SLC34A1 levels (By similarity) . Acts ly on the parathyroid to decrease PTH secretion (By similarity) . Regulator of vitamin-D metabolism (By similarity) . Negatively regulates osteoblasts differentiation and matrix mineralization (By similarity) . Upregulates EGR1 expression in the presence of KL. .

1. Entrez Gene: FGF23 fibroblast growth factor 23. 2. Fukumoto S (2008) . Physiological regulation and disorders of phosphate metabolism--pivotal role of fibroblast growth factor 23. Intern. Med. 47 (5) : 337–43. 3. Yamashita T, Yoshioka M, Itoh N (October 2000) . Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain. Biochem. Biophys. Res. Commun.277 (2) : 494–8.