Anti-Fatty Acid Synthase/FASN Antibody Picoband® Fluoro488 Conjugated
Selected Variant
PB9865-Fluoro488
Size: 100 µg/Vial
Product Specifications
Background
Fatty acid synthase (FAS) is an enzyme that in humans is encoded by the FASN gene. It is mapped to 17q25. The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha.
Synonyms
Fatty acid synthase;2.3.1.85; [Acyl-carrier-protein] S-acetyltransferase;2.3.1.38; [Acyl-carrier-protein] S-malonyltransferase;2.3.1.39;3-oxoacyl-[acyl-carrier-protein] synthase;2.3.1.41;3-oxoacyl-[acyl-carrier-protein] reductase;1.1.1.100;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;4.2.1.59; Enoyl-[acyl-carrier-protein] reductase;1.3.1.39; Oleoyl-[acyl-carrier-protein] hydrolase;3.1.2.14; FASN; FAS
Gene Name
FASN
Gene ID
2194
UniProt
P49327
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E. coli-derived human FASN recombinant protein (Position: M1-E226) . Human FASN shares 90.3% and 90.7% amino acid (aa) sequence identity with mouse and rat FASN, respectively.
Clonality
Polyclonal
Tissue Specificity
Ubiquitous. Prominent expression in brain, lung, and liver. .
Applications
Flow Cytometry
Field of Research
Cancer, Cancer Metabolism, Cardiovascular, Energy Metabolism, Energy Transfer Pathways, Fatty Acid Oxidation, Fatty Acids, Integration Of Energy, Integration Of Energy Metabolism, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Lipids/Lipoproteins, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism of Lipids and Lipoproteins, Neurology Process, Neuroscience, Obesity, Pathways and Processes, Redox Metabolism, Signal Transduction, Tumor Biomarkers
Purification
Immunogen affinity purified.
Form
Liquid
Function
Fatty acid synthetase catalyzes the formation of long- chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein.
References & Citations
1. Entrez Gene: FASN fatty acid synthase. 2. Jayakumar A, Tai MH, Huang WY, al-Feel W, Hsu M, Abu-Elheiga L, Chirala SS, Wakil SJ (Oct 1995) . Human fatty acid synthase: properties and molecular cloning. Proc Natl Acad Sci U S A 92 (19) : 8695–9. 3. Smith S, Witkowski A, Joshi AK (July 2003) . Structural and functional organization of the animal fatty acid synthase. Prog. Lipid Res. 42 (4) : 289–317.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
273427 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Fatty acid synthase
Subcellular Location
Cytoplasm . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Protein Name
Fatty acid synthase
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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