Anti-CXCL5 Antibody Picoband®

C-X-C motif chemokine 5?or ENA-78 is a?protein?that in humans is encoded by the?CXCL5?gene. The protein encoded by this gene, CXCL5 is a small?cytokine?belonging to the CXC?chemokine?family. It is produced following stimulation of cells with the inflammatory cytokines?interleukin-1?or?tumor necrosis factor-alpha.?Expression of CXCL5 has also been observed ineosinophils, and can be inhibited with the type II?interferon?IFN-γ. This chemokine stimulates the chemotaxis of neutrophils possessing?angiogenic?properties. It elicits these effects by interacting with the cell surface?chemokine receptor?CXCR2.?The?gene?for CXCL5 is encoded on four?exons?and is located on human?chromosome 4?amongst several other CXC chemokine genes.?CXCL5 has been implicated in connective tissue remodelling.?Also, CXCL5 has been described to regulate neutrophil homeostasis.

E. coli-derived rat CXCL5 recombinant protein (Position: A38-Q130) . Rat CXCL5 shares 58.7% and 76.3% amino acid (aa) sequence identity with human and mouse CXCL5, respectively.

1. Entrez Gene: CXCL5 chemokine (C-X-C motif) ligand 5. 2. Chang MS, McNinch J, Basu R, Simonet S (Nov 1994) . Cloning and characterization of the human neutrophil-activating peptide (ENA-78) gene. J Biol Chem 269 (41) : 25277–82. 3. Persson T, Monsef N, Andersson P, Bjartell A, Malm J, Calafat J, Egesten A (2003) . Expression of the neutrophil-activating CXC chemokine ENA-78/CXCL5 by human eosinophils. Clin. Exp. Allergy 33 (4) : 531–7.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.