Anti-CXCL2 Antibody Picoband®

Chemokine (C-X-C motif) ligand 2  (CXCL2) is a small  cytokine  belonging to the CXC  chemokine  family that is also called  macrophage inflammatory protein 2-alpha  (MIP2-alpha),   Growth-regulated protein beta  (Gro-beta) and  Gro oncogene-2 (Gro-2) . CXCL2 is 90% identical in  amino acid  sequence as a related chemokine,   CXCL1. This chemokine is secreted by monocytes  and  macrophages  and is  chemotactic  for  polymorphonuclear leukocytes  and  hematopoietic stem cells. The gene for CXCL2 is located on human  chromosome 4  in a cluster of other CXC chemokines. CXCL2 mobilizes cells by interacting with a cell surface  chemokine receptor  called  CXCR2.

C-X-C motif chemokine 2; Cytokine-induced neutrophil chemoattractant 3; CINC-3; Macrophage inflammatory protein 2; MIP2; Cxcl2; Cinc3, Mip-2, Mip2, Scyb2

E. coli-derived rat CXCL2 recombinant protein (Position: S32-N100) . Rat CXCL2 shares 62.3% and 88.4% amino acid (aa) sequence identity with huamn and mouse CXCL2, respectively.

Chemotactic for human polymorphonuclear leukocytes but does not induce chemokinesis or an oxidative burst. Contributes to neutrophil activation during inflammation.

1. Iida N., Grotendorst G.R. Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue. Mol. Cell. Biol. 10:5596-5599, 1990. 2. Pelus LM, Fukuda S. Peripheral blood stem cell mobilization: the CXCR2 ligand GRObeta rapidly mobilizes hematopoietic stem cells with enhanced engraftment properties. Exp Hematol. 2006 Aug;34 (8) :1010-20. 3. Wolpe, S. D., Sherry, B., Juers, D., Davatelis, G., Yurt, R. W., Cerami, A. Identification and characterization of macrophage inflammatory protein 2. Proc. Nat. Acad. Sci. 86: 612-616, 1989.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.