Anti-CXCL2 Antibody Picoband® Fluoro594 Conjugated

Chemokine (C-X-C motif) ligand 2  (CXCL2) is a small  cytokine  belonging to the CXC  chemokine  family that is also called  macrophage inflammatory protein 2-alpha  (MIP2-alpha),   Growth-regulated protein beta  (Gro-beta) and  Gro oncogene-2 (Gro-2) . CXCL2 is 90% identical in  amino acid  sequence as a related chemokine,   CXCL1. This chemokine is secreted by monocytes  and  macrophages  and is  chemotactic  for  polymorphonuclear leukocytes  and  hematopoietic stem cells. The gene for CXCL2 is located on human  chromosome 4  in a cluster of other CXC chemokines. CXCL2 mobilizes cells by interacting with a cell surface  chemokine receptor  called  CXCR2.

C-X-C motif chemokine 2; Growth-regulated protein beta; Gro-beta; Macrophage inflammatory protein 2-alpha; MIP2-alpha; GRO-beta (5-73) ; GRO-beta-T; Hematopoietic synergistic factor; HSF; SB-251353; CXCL2; GRO2, GROB, MIP2A, SCYB2

E. coli-derived human CXCL2 recombinant protein (Position: T39-N107) . Human CXCL2 shares 66.7% and 62.3% amino acid (aa) sequence identity with mouse and rat CXCL2, respectively.

Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta (5-73) shows a highly enhanced hematopoietic activity. .

1. Iida N., Grotendorst G.R. Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue. Mol. Cell. Biol. 10:5596-5599, 1990. 2. Pelus LM, Fukuda S. Peripheral blood stem cell mobilization: the CXCR2 ligand GRObeta rapidly mobilizes hematopoietic stem cells with enhanced engraftment properties. Exp Hematol. 2006 Aug;34 (8) :1010-20. 3. Wolpe, S. D., Sherry, B., Juers, D., Davatelis, G., Yurt, R. W., Cerami, A. Identification and characterization of macrophage inflammatory protein 2. Proc. Nat. Acad. Sci. 86: 612-616, 1989.