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Anti-Cathepsin G/CTSG Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Cathepsin G is an enzymatic protein belonging to the peptidase or protease families. In humans, it is coded by the CTSG?gene.?This gene is mapped to 14q12. In transgenic mice, it was found that?human Cathepsin G gene was expressed in early myeloid precursors in a manner coordinate with the expression of the endogenous murine gene in the bone marrow and spleen. The protein encoded by this?gene, a member of the?peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear?leukocytes.?The encoded protease has a specificity similar to that of?chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in?connective tissue?remodeling at sites of?inflammation.?

Synonyms

Cathepsin G;3.4.21.20; Vimentin-specific protease; VSP; Ctsg

Gene Name

Ctsg

Gene ID

13035

UniProt

P28293

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived mouse Cathepsin G recombinant protein (Position: I21-T261) . Mouse Cathepsin G shares 70.2% amino acid (aa) sequence identity with human Cathepsin G.

Clonality

Polyclonal

Tissue Specificity

Expressed in the aorta extrcellular space (at protein level) . .

Applications

Flow Cytometry

Field of Research

Cell Biology, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

This vimentin-specific protease may regulate the reorganization of vimentin filaments, occurring during cell differentiation, movement and mitosis.

References & Citations

1. Entrez Gene: CTSG cathepsin G. 2. Grisolano, J. L., Sclar, G. M., Ley, T. J. Early myeloid cell-specific expression of the human Casthepsin G gene in transgenic mice. Proc. Nat. Acad. Sci. 91: 8989-8993, 1994.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

29096 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Cathepsin G

Subcellular Location

Membrane. Strongly associated with membranes.

Protein Name

Cathepsin G

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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