Anti-CD46 Antibody Picoband®

CD46 complement regulatory protein, ?also known as?CD46 (cluster of differentiation?46) and?Membrane Cofactor Protein, ?is a?protein?which in humans is encoded by the?CD46 gene. The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. And the encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.?

A synthetic peptide corresponding to a sequence at the N-terminus of mouse CD46, different from the related human sequence by twelve amino acids, and from the related rat sequence by nine amino acids.

1. Entrez Gene: CD46 CD46 molecule, complement regulatory protein. 2. Liszewski MK, Post TW, Atkinson JP (1991) . Membrane cofactor protein (MCP or CD46) : newest member of the regulators of complement activation gene cluster.Annu. Rev. Immunol. 9 (1) : 431–55. 3. Taylor CT, Biljan MM, Kingsland CR, Johnson PM (May 1994) . Inhibition of human spermatozoon-oocyte interaction in vitro by monoclonal antibodies to CD46 (membrane cofactor protein) . Hum. Reprod.9 (5) : 907–11.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Isoform 1: Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane; Single-pass type I membrane protein. Inner acrosomal membrane of spermatozoa.