Anti-SULT2B1 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Sulfotransferase family cytosolic 2B member 1 is an enzyme that in humans is encoded by the SULT2B1 gene. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. And this gene sulfates dehydroepiandrosterone but not 4-nitrophenol, a typical substrate for the phenol and estrogen sulfotransferase subfamilies. Two alternatively spliced variants that encode different isoforms have been described.
Synonyms
Sulfotransferase family cytosolic 2B member 1; ST2B1; Sulfotransferase 2B1;2.8.2.2; Alcohol sulfotransferase; Hydroxysteroid sulfotransferase 2; SULT2B1; HSST2
Gene Name
SULT2B1
Gene ID
6820
UniProt
O00204
Host
Rabbit
Reactivity
Human, Rat
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human SULT2B1, different from the related mouse sequence by six amino acids, and from the related rat sequence by five amino acids.
Clonality
Polyclonal
Tissue Specificity
Expressed highly in placenta, prostate and trachea and lower expression in the small intestine and lung. .
Applications
Flow Cytometry
Field of Research
Cancer, Cardiovascular, Cholesterol Metabolism, Drug Metabolism, Growth Factors/Hormones, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Lipids/Lipoproteins, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol. .
References & Citations
1. Entrez Gene: SULT2B1 sulfotransferase family, cytosolic, 2B, member 1. 2. Geese WJ, Raftogianis RB (2001) . Biochemical characterization and tissue distribution of human SULT2B1. Biochem. Biophys. Res. Commun. 288 (1) : 280–9. 3. Her C, Wood TC, Eichler EE, Mohrenweiser HW, Ramagli LS, Siciliano MJ, Weinshilboum RM (Dec 1998) . Human hydroxysteroid sulfotransferase SULT2B1: two enzymes encoded by a single chromosome 19 gene. Genomics 53 (3) : 284–95.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
41308 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Sulfotransferase family cytosolic 2B member 1
Subcellular Location
Cytoplasm. Microsome. Nucleus. Phosphorylation of Ser-348 is required for translocation to the nucleus.
Protein Name
Sulfotransferase family cytosolic 2B member 1
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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