Anti-Thymidine Kinase 1/TK1 Antibody Picoband® Fluoro550 Conjugated
Product Specifications
Background
Thymidine kinase 1, soluble (gene name TK1), is a human thymidine kinase. Thymidine kinase catalyzes the phosphorylation of thymidine to deoxythymidine monophosphate. This gene is mapped to 17q23.2-q25.3. It is estimated that the maximal size of the TK1 gene is 14 kb and its minimal size between 4 and 5 kb. The gene contains many noncoding inserts and numerous Alu sequences. There are two forms of this protein, which have been identified in animal cells, one in cytosol and one in mitochondria. Activity of the cytosolic enzyme is high in proliferating cells and peaks during the S-phase of the cell cycle; it is very low in resting cells.
Synonyms
Thymidine kinase, cytosolic;2.7.1.21; TK1
Gene Name
TK1
Gene ID
7083
UniProt
P04183
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
E. coli-derived human TK1 recombinant protein (Position: S2-N234) . Human TK1 shares 87.1% and 91.7% amino acid (aa) sequence identity with mouse and rat TK1, respectively.
Clonality
Polyclonal
Tissue Specificity
Found in all tissues examined, most abundant in placenta and least abundant in brain and heart.
Applications
Flow Cytometry
Field of Research
DNA/RNA, DNA Synthesis, Epigenetics and Nuclear Signaling
Purification
Immunogen affinity purified.
Form
Liquid
Function
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.
References & Citations
1. Entrez Gene: Thymidine kinase 1, soluble. 2. Bradshaw, H. D., Jr., Deininger, P. L. Human thymidine kinase gene: molecular cloning and nucleotide sequence of a cDNA expressible in mammalian cells. Molec. Cell. Biol. 4: 2316-2320, 1984. 3. Kuo, W.-L., Hirschhorn, R., Huie, M. L., Hirschhorn, K. Localization and ordering of acid alpha-glucosidase (GAA) and thymidine kinase (TK1) by fluorescence in situ hybridization. Hum. Genet. 97: 404-406, 1996.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Product Datasheet
https://www.bosterbio.com/datasheet?sku=PB9832-Fluoro550
Calculated Molecular Weight
25469 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Thymidine kinase, cytosolic
Subcellular Location
Cytoplasm.
Protein Name
Thymidine kinase, cytosolic
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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