What sizes are available for Anti-Munc18-1/STXBP1 Antibody Picoband® Fluoro647 Conjugated?

Anti-Munc18-1/STXBP1 Antibody Picoband® Fluoro647 Conjugated is available in the following size(s): 100 µg/Vial.

Is there an additional fee for hazardous or dry ice shipping of this product?

Yes, if this product requires dry ice or is classed as hazardous for transport, the additional fee will be explicitly shown in your quotation before you confirm the order, so there are no surprise charges later.

How many freeze-thaw cycles can this product tolerate?

We recommend aliquoting the product upon receipt to avoid repeated freeze-thaw cycles, which can reduce activity and stability. This is your responsibility once the product has been delivered.

Is antigen retrieval required for IHC with this antibody?

Recommended antigen retrieval methods, where applicable, are listed on the datasheet under the IHC protocol section.

Anti-Munc18-1/STXBP1 Antibody Picoband® Fluoro647 Conjugated

Q: What is the catalog number for Anti-Munc18-1/STXBP1 Antibody Picoband® Fluoro647 Conjugated?

The catalog number for Anti-Munc18-1/STXBP1 Antibody Picoband® Fluoro647 Conjugated is PB9819-Fluoro647.

Product Specifications

Background

Syntaxin-binding protein 1, also known as Munc18-1, is a protein that in humans is encoded by the STXBP1 gene. By fluorescence in situ hybridization, the STXBP1 gene is mapped to chromosome 9q34.1. This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described.

Synonyms

Syntaxin-binding protein 1; MUNC18-1; N-Sec1; Protein unc-18 homolog 1; Unc18-1; Protein unc-18 homolog A; Unc-18A; p67; STXBP1; UNC18A

Gene Name

STXBP1

Gene ID

6812

UniProt

P61764

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human Munc18-1, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Tissue Specificity

Brain and spinal cord. Highly enriched in axons.

Applications

Flow Cytometry

Field of Research

Cancer, Cancer Metabolism, Cell Type Marker, Energy Transfer Pathways, Integration Of Energy, Integration Of Energy Metabolism, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Neuron Marker, Neuroscience, Neurotransmission, Pathways and Processes, Secretory Vesicles, Synapse Marker

Purification

Immunogen affinity purified.

Form

Liquid

Function

May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.

References & Citations

1. Entrez Gene: STXBP1 syntaxin binding protein 1. 2. Fisher, R. J., Pevsner, J., Burgoyne, R. D. Control of fusion pore dynamics during exocytosis by Munc18. Science 291: 875-878, 2001. 3. Swanson DA, Steel JM, Valle D (Jun 1998) . Identification and characterization of the human ortholog of rat STXBP1, a protein implicated in vesicle trafficking and neurotransmitter release. Genomics 48 (3) : 373–6.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

67569 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

Gene Name Synonym

Syntaxin-binding protein 1

Subcellular Location

Cytoplasm, cytosol . Membrane; Peripheral membrane protein.

Protein Name

Syntaxin-binding protein 1

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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