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Anti-RAB14 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Ras-related protein Rab-14 is a protein that in humans is encoded by the RAB14 gene. It is mapped to 9q33.2 based on an alignment of the RAB14 sequence with the genomic sequence. RAB14 belongs to the large RAB family of low molecular mass GTPases that are involved in intracellular membrane trafficking. These proteins act as molecular switches that flip between an inactive GDP-bound state and an active GTP-bound state in which they recruit downstream effector proteins onto membranes.

Synonyms

Ras-related protein Rab-14; RAB14

Gene Name

RAB14

Gene ID

51552

UniProt

P61106

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human RAB14, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Tissue Specificity

Overexpressed in bladder cancer cells (PubMed:17409436) . .

Applications

Flow Cytometry

Field of Research

Golgi Proteins, Organelle Proteins, Protein Trafficking, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity) . Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N- cadherin/CDH2 shedding and cell-cell adhesion. .

References & Citations

1. Entrez Gene: RAB14 RAB14, member RAS oncogene family. 2. de Leeuw HP, Koster PM, Calafat J, Janssen H, van Zonneveld AJ, van Mourik JA, Voorberg J (Dec 1998) . Small GTP-binding proteins in human endothelial cells. Br J Haematol 103 (1) : 15–9. 3. Junutula JR, De Maziere AM, Peden AA, Ervin KE, Advani RJ, van Dijk SM, Klumperman J, Scheller RH (Apr 2004) . Rab14 is involved in membrane trafficking between the Golgi complex and endosomes. Mol Biol Cell15 (5) : 2218–29.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

24 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Ras-related protein Rab-14

Subcellular Location

Recycling endosome . Early endosome membrane ; Lipid-anchor ; Cytoplasmic side . Golgi apparatus membrane ; Lipid-anchor ; Cytoplasmic side . Golgi apparatus, trans-Golgi network membrane ; Lipid-anchor ; Cytoplasmic side . Cytoplasmic vesicle, phagosome . Recruited to recycling endosomes by DENND6A (PubMed:22595670) . Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211) . .

Protein Name

Ras-related protein Rab-14

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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