Anti-Rab18 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Ras-related protein Rab-18 is a protein that in humans is encoded by the RAB18 gene. It is a ubiquitously expressed protein with particularly high expression in the brain. The protein encoded by this gene is a member of a family of Ras-related small GTPases that regulate membrane trafficking in organelles and transport vesicles. Knockdown studies in zebrafish suggest that this protein may have a role in eye and brain development. Mutations in this gene are associated with Warburg micro syndrome type 3. Alternatively spliced transcript variants have been found for this gene.
Synonyms
Ras-related protein Rab-18; RAB18
Gene Name
RAB18
Gene ID
22931
UniProt
Q9NP72
Host
Rabbit
Reactivity
Human, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Rab18, identical to the related mouse sequence, and different from the related rat sequence by one amino acid.
Clonality
Polyclonal
Tissue Specificity
Ubiquitous.
Applications
Flow Cytometry
Field of Research
G Protein Signaling, Protein Trafficking, Ras Family, Signal Transduction, Signaling Pathway, Small G Proteins, Vesicle Transport
Purification
Immunogen affinity purified.
Form
Liquid
Function
Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration. .
References & Citations
1. Entrez Gene: RAB18 RAB18, member RAS oncogene family. 2. Lütcke A, Parton RG, Murphy C, Olkkonen VM, Dupree P, Valencia A, Simons K, Zerial M (December 1994) . Cloning and subcellular localization of novel rab proteins reveals polarized and cell type-specific expression. J. Cell. Sci. 107 (12) : 3437–48. 3. Schafer U, Seibold S, Schneider A, Neugebauer E (Feb 2000) . Isolation and characterisation of the human rab18 gene after stimulation of endothelial cells with histamine. FEBS Lett 466 (1) : 148–54.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
22977 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Ras-related protein Rab-18
Subcellular Location
Cell membrane ; Lipid-anchor ; Cytoplasmic side .
Protein Name
Ras-related protein Rab-18
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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