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Anti-PON2 Antibody Picoband®

Boster Bio Anti-PON2 Antibody Picoband® catalog # PB9779. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

PON2 is an enzyme that in humans is encoded by the PON2 gene. It is mapped to 7q21.3. This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones and important bacterial quorum-sensing mediators suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes.

Synonyms

Serum paraoxonase/arylesterase 2; PON 2;3.1.1.2;3.1.1.81; Aromatic esterase 2; A-esterase 2; Serum aryldialkylphosphatase 2; PON2

Gene Name

PON2

Gene ID

5445

UniProt

Q15165

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human PON2, different from the related mouse and rat sequences by four amino acids.

Clonality

Polyclonal

Tissue Specificity

Widely expressed with highest expression in liver, lung, placenta, testis and heart. .

Applications

WB

Field of Research

Cardiovascular, Drug Metabolism, Lipids/Lipoproteins, Metabolic Signaling Pathways, Metabolism, Neurodegenerative Disease, Neurology Process, Neuroscience, Pathways and Processes, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis. .

References & Citations

1. Entrez Gene: PON2 paraoxonase 2 2. Mochizuki H, Scherer SW, Xi T, Nickle DC, Majer M, Huizenga JJ, Tsui LC, Prochazka M (Aug 1998) . Human PON2 gene at 7q21.3: cloning, multiple mRNA forms, and missense polymorphisms in the coding sequence. Gene 213 (1–2) : 149–57. 3. Primo-Parmo SL, Sorenson RC, Teiber J, La Du BN (Sep 1996) . The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family. Genomics 33 (3) : 498–507.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=PB9779

Product MSDS

https://www.bosterbio.com/msds?sku=PB9779

Calculated Molecular Weight

39397 MW

Observed Molecular Weight

39 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Serum paraoxonase/arylesterase 2

Subcellular Location

Membrane ; Peripheral membrane protein .

Protein Name

Serum paraoxonase/arylesterase 2

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

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