Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-PIGR Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Polymeric immunoglobulin receptor is a protein that in humans is encoded by the PIGR gene. It is a Fc receptor which facilitates the secretion of the soluble polymeric isoforms of immunoglobulin A and immunoglobulin M. This gene is mapped to 1q31-q41. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.

Synonyms

Polymeric immunoglobulin receptor; PIgR; Poly-Ig receptor; Hepatocellular carcinoma-associated protein TB6; Secretory component; PIGR

Gene Name

PIGR

Gene ID

5284

UniProt

P01833

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human PIGR, different from the related rat sequence by eighteen amino acids.

Clonality

Polyclonal

Tissue Specificity

Widely expressed, with highest expression in liver and kidney.

Applications

Flow Cytometry

Field of Research

Immunoglobulins, Immunology, Receptors

Purification

Immunogen affinity purified.

Form

Liquid

Function

This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.

References & Citations

1. Entrez Gene: PIGR polymeric immunoglobulin receptor. 2. Hood L, Kronenberg M, Hunkapiller T (Feb 1985) . T cell antigen receptors and the immunoglobulin supergene family. Cell 40 (2) : 225–9. 3. Kaetzel CS (Aug 2005) . The polymeric immunoglobulin receptor: bridging innate and adaptive immune responses at mucosal surfaces. Immunological Reviews 206: 83–99.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

83284 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Polymeric immunoglobulin receptor

Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Protein Name

Polymeric immunoglobulin receptor

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Influenza A (Nucleoprotein) (MaxLight 405) discontinued
I7650-84B-ML405 100 µL

Influenza A (Nucleoprotein) (MaxLight 405) discontinued

Ask
View Details
SIRT1 Protein, Human, Recombinant (His Tag)
MBS8120962-01 0.1 mg

SIRT1 Protein, Human, Recombinant (His Tag)

Ask
View Details
SIRT1 Protein, Human, Recombinant (His Tag)
MBS8120962-02 5x 0.1 mg

SIRT1 Protein, Human, Recombinant (His Tag)

Ask
View Details
Recombinant Arabidopsis thaliana Protein disulfide-isomerase like 2-2 (PDIL2-2)
MBS1449901-01 0.02 mg (E-Coli)

Recombinant Arabidopsis thaliana Protein disulfide-isomerase like 2-2 (PDIL2-2)

Ask
View Details
Recombinant Arabidopsis thaliana Protein disulfide-isomerase like 2-2 (PDIL2-2)
MBS1449901-02 0.02 mg (Yeast)

Recombinant Arabidopsis thaliana Protein disulfide-isomerase like 2-2 (PDIL2-2)

Ask
View Details
Recombinant Arabidopsis thaliana Protein disulfide-isomerase like 2-2 (PDIL2-2)
MBS1449901-03 0.1 mg (E-Coli)

Recombinant Arabidopsis thaliana Protein disulfide-isomerase like 2-2 (PDIL2-2)

Ask
View Details