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Anti-PGRMC1 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Progesterone receptor membrane component 1 (PGRMC1) is a protein which co-purifies with progesterone binding proteins in the liver and ovary. In humans, the PGRMC1 protein is encoded by the PGRMC1 gene. The Sigma-2 receptor was recently identified as potentially being the same as PGRMC1. The sole biochemical function of PGRMC1 is heme-binding. PGRMC1 shares key structural motifs with cytochrome b5. It binds and activates P450 proteins, which are important in drug, hormone and lipid metabolism. Also, PGRMC1 binds to PAIR-BP1 (plasminogen activator inhibitor RNA-binding protein-1) . However, its expression outside of the reproductive tract and in males suggests multiple functions for the protein. These may include binding to Insig (insulin-induced gene), which regulates cholesterol synthesis.

Synonyms

Membrane-associated progesterone receptor component 1; mPR; PGRMC1; HPR6.6, PGRMC

Gene Name

PGRMC1

Gene ID

10857

UniProt

O00264

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human PGRMC1, identical to the related mouse sequence, and different from the related rat sequence by two amino acids.

Clonality

Polyclonal

Tissue Specificity

Widely expressed, with highest expression in liver and kidney.

Applications

Flow Cytometry

Field of Research

Associated Proteins, Cancer, Cardiovascular, Growth Factors/Hormones, Hypoxia, Oncoproteins, Oncoproteins/Suppressors, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Receptor for progesterone. .

References & Citations

1. Gerdes D, Wehling M, Leube B, Falkenstein E (Jul 1998) . Cloning and tissue expression of two putative steroid membrane receptors.Biological Chemistry 379 (7) : 907–11. 2. Meyer C, Schmid R, Scriba PC, Wehling M (Aug 1996) . Purification and partial sequencing of high-affinity progesterone-binding site (s) from porcine liver membranes. European Journal of Biochemistry / FEBS 239 (3) : 726–31. 3. Xu J, Zeng C, Chu W, Pan F, Rothfuss JM, Zhang F, Tu Z, Zhou D, Zeng D, Vangveravong S, Johnston F, Spitzer D, Chang KC, Hotchkiss RS, Hawkins WG, Wheeler KT, Mach RH (2011) . Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site. Nature Communications 2 (2) : 380.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

21671 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Membrane-associated progesterone receptor component 1

Subcellular Location

Microsome membrane ; Single- pass membrane protein . Endoplasmic reticulum membrane ; Single-pass membrane protein .

Protein Name

Membrane-associated progesterone receptor component 1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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