Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-PGRMC1 Antibody Picoband®

Boster Bio Anti-PGRMC1 Antibody Picoband® catalog # PB9775. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Progesterone receptor membrane component 1 (PGRMC1) is a protein which co-purifies with progesterone binding proteins in the liver and ovary. In humans, the PGRMC1 protein is encoded by the PGRMC1 gene. The Sigma-2 receptor was recently identified as potentially being the same as PGRMC1. The sole biochemical function of PGRMC1 is heme-binding. PGRMC1 shares key structural motifs with cytochrome b5. It binds and activates P450 proteins, which are important in drug, hormone and lipid metabolism. Also, PGRMC1 binds to PAIR-BP1 (plasminogen activator inhibitor RNA-binding protein-1) . However, its expression outside of the reproductive tract and in males suggests multiple functions for the protein. These may include binding to Insig (insulin-induced gene), which regulates cholesterol synthesis.

Synonyms

Membrane-associated progesterone receptor component 1; mPR; PGRMC1; HPR6.6, PGRMC

Gene Name

PGRMC1

Gene ID

10857

UniProt

O00264

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human PGRMC1, identical to the related mouse sequence, and different from the related rat sequence by two amino acids.

Clonality

Polyclonal

Tissue Specificity

Widely expressed, with highest expression in liver and kidney.

Applications

IHC, WB

Field of Research

Associated Proteins, Cancer, Cardiovascular, Growth Factors/Hormones, Hypoxia, Oncoproteins, Oncoproteins/Suppressors, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Receptor for progesterone. .

References & Citations

1. Gerdes D, Wehling M, Leube B, Falkenstein E (Jul 1998) . Cloning and tissue expression of two putative steroid membrane receptors.Biological Chemistry 379 (7) : 907–11. 2. Meyer C, Schmid R, Scriba PC, Wehling M (Aug 1996) . Purification and partial sequencing of high-affinity progesterone-binding site (s) from porcine liver membranes. European Journal of Biochemistry / FEBS 239 (3) : 726–31. 3. Xu J, Zeng C, Chu W, Pan F, Rothfuss JM, Zhang F, Tu Z, Zhou D, Zeng D, Vangveravong S, Johnston F, Spitzer D, Chang KC, Hotchkiss RS, Hawkins WG, Wheeler KT, Mach RH (2011) . Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site. Nature Communications 2 (2) : 380.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

21671 MW

Observed Molecular Weight

26 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Membrane-associated progesterone receptor component 1

Subcellular Location

Microsome membrane ; Single- pass membrane protein . Endoplasmic reticulum membrane ; Single-pass membrane protein .

Protein Name

Membrane-associated progesterone receptor component 1

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

[Sar9] Substance P
MBS3847714-01 1 mg

[Sar9] Substance P

Ask
View Details
[Sar9] Substance P
MBS3847714-02 5 mg

[Sar9] Substance P

Ask
View Details
[Sar9] Substance P
MBS3847714-03 10 mg

[Sar9] Substance P

Ask
View Details
[Sar9] Substance P
MBS3847714-04 5x 10 mg

[Sar9] Substance P

Ask
View Details
Rabbit anti-human E3 ubiquitin-protein ligase CBL-C polyclonal Antibody(CBLC)
MBS1491737-01 0.05 mL

Rabbit anti-human E3 ubiquitin-protein ligase CBL-C polyclonal Antibody(CBLC)

Ask
View Details
Rabbit anti-human E3 ubiquitin-protein ligase CBL-C polyclonal Antibody(CBLC)
MBS1491737-02 0.1 mL

Rabbit anti-human E3 ubiquitin-protein ligase CBL-C polyclonal Antibody(CBLC)

Ask
View Details