Anti-PAX6 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Paired box protein Pax-6, also known as aniridia type II protein (AN2) or oculorhombin, is a protein that in humans is encoded by the PAX6 gene. This gene encodes a homeobox and paired domain-containing protein that binds DNA and functions as a regulator of transcription. Activity of this protein is key in the development of neural tissues, particularly the eye. In addition, this gene is regulated by multiple enhancers located up to hundreds of kilobases distant from this locus. Mutations in this gene or in the enhancer regions can cause ocular disorders such as aniridia and Peter's anomaly. Use of alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms.
Synonyms
Paired box protein Pax-6; Aniridia type II protein; Oculorhombin; PAX6; AN2
Gene Name
PAX6
Gene ID
5080
UniProt
P26367
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human PAX6, identical to the related mouse and rat sequences.
Clonality
Polyclonal
Tissue Specificity
Fetal eye, brain, spinal cord and olfactory epithelium. Isoform 5a is less abundant than the PAX6 shorter form.
Applications
Flow Cytometry
Field of Research
Cell Type Marker, Developmental Biology, Developmental Families, Domain Families, Epigenetics and Nuclear Signaling, Lineage Markers, Lineage Specification, Neural Signal Transduction, Neurology Process, Neuroscience, Organogenesis, Stem Cells, Transcription
Purification
Immunogen affinity purified.
Form
Liquid
Function
Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity) . Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity) . Isoform 5a appears to function as a molecular switch that specifies target genes. .
References & Citations
1. Gehring WJ, Ikeo K (September 1999) . Pax 6: mastering eye morphogenesis and eye evolution. Trends Genet. 15 (9) : 371–7. 2. Jordan T, Hanson I, Zaletayev D, Hodgson S, Prosser J, Seawright A, Hastie N, van Heyningen V (August 1992) . The human PAX6 gene is mutated in two patients with aniridia. Nat. Genet. 1 (5) : 328–32. 3. Walcher T, Xie Q, Sun J, Irmler M, Beckers J, Öztürk T, Niessing D, Stoykova A, Cvekl A, Ninkovic J, Götz M (March 2013) . Functional dissection of the paired domain of Pax6 reveals molecular mechanisms of coordinating neurogenesis and proliferation. Development 140 (5) : 1123–36.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
46683 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Paired box protein Pax-6
Subcellular Location
Nucleus.
Protein Name
Paired box protein Pax-6
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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