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Anti-Cdc25C Antibody Picoband®

Boster Bio Anti-Cdc25C Antibody Picoband® catalog # PB9756. Tested in WB, ICC/IF, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

M-phase inducer phosphatase 3 is an enzyme that in humans is encoded by the CDC25C gene. This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It s dephosphorylation of cyclin B-bound CDC2 (CDK1) and triggers entry into mitosis. Also, it is thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.

Synonyms

M-phase inducer phosphatase 3;3.1.3.48; Dual specificity phosphatase Cdc25C; CDC25C

Gene Name

CDC25C

Gene ID

995

UniProt

P30307

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human Cdc25C recombinant protein (Position: K175-P473) . Human Cdc25C shares 78.2% amino acid (aa) sequence identity with mouse Cdc25C.

Clonality

Polyclonal

Tissue Specificity

Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethral and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart. .

Applications

WB, ICC/IF, Flow Cytometry

Field of Research

Cell Biology, Cell Cycle, Epigenetics and Nuclear Signaling, Kinases/Phosphatases

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. ly dephosphorylates CDK1 and activates its kinase activity. .

References & Citations

1. Entrez Gene: CDC25C cell division cycle 25 homolog C (S. pombe) . 2. Gould KL, Moreno S, Tonks NK, Nurse P (Feb 1991) . Complementation of the mitotic activator, p80cdc25, by a human protein-tyrosine phosphatase. Science 250 (4987) : 1573–6. 3. Sartor H, Ehlert F, Grzeschik KH, et al. (1992) . Assignment of two human cell cycle genes, CDC25C and CCNB1, to 5q31 and 5q12, respectively. Genomics 13 (3) : 911–2.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

53 kDa

Observed Molecular Weight

53 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

M-phase inducer phosphatase 3

Subcellular Location

Nucleus .

Protein Name

M-phase inducer phosphatase 3

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

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