Anti-HSD11B2 Antibody Picoband®

Corticosteroid 11-β-dehydrogenase isozyme 2, also known as?11-β-hydroxysteroid dehydrogenase 2, ?is an enzyme?that in humans is encoded by the?HSD11B2?gene. There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.

Corticosteroid 11-beta-dehydrogenase isozyme 2;1.1.1.-;11-beta-hydroxysteroid dehydrogenase type 2;11-DH2;11-beta-HSD2;11-beta-hydroxysteroid dehydrogenase type II;11-HSD type II;11-beta-HSD type II; NAD-dependent 11-beta-hydroxysteroid dehydrogenase;11-beta-HSD; Short chain dehydrogenase/reductase family 9C member 3; HSD11B2; HSD11K , SDR9C3

A synthetic peptide corresponding to a sequence at the C-terminus of human HSD11B2, different from the related mouse sequence by five amino acids, and from the related rat sequence by three amino acids.

Expressed in kidney, pancreas, prostate, ovary, small intestine and colon. At midgestation, expressed at high levels in placenta and in fetal kidney and, at much lower levels, in fetal lung and testis (PubMed:8530071) . .

Atherosclerosis, Cancer, Cancer Metabolism, Cardiovascular, Cell Biology, Growth Factors/Hormones, Heart Disease, Metabolism, Metabolism Processes, Pathways and Processes, Response To Hypoxia, Signal Transduction

Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.

1. Albiston AL, Obeyesekere VR, Smith RE, Krozowski ZS (November 1994) . Cloning and tissue distribution of the human 11 beta-hydroxysteroid dehydrogenase type 2 enzyme. Mol. Cell. Endocrinol. 105 (2) : R11–7. 2. Brown RW, Chapman KE, Kotelevtsev Y, Yau JL, Lindsay RS, Brett L, Leckie C, Murad P, Lyons V, Mullins JJ, Edwards CR, Seckl JR (February 1996) . Cloning and production of antisera to human placental 11 beta-hydroxysteroid dehydrogenase type 2. Biochem. J. 313 (Pt 3) (Pt 3) : 1007–17.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.