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Anti-Prealbumin/TTR Antibody Picoband® Fluoro647 Conjugated

Selected Variant

PB9749-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

Transthyretin (TTR) is also known as prealbumin. It is mapped to chromosome region 18q11.2-q12.1. This gene encodes a carrier protein responsible for the transport of thyroid hormones and retinol. The protein consists of a tetramer of identical subunits. Due to increased stability of the tetramer form of this encoded protein in mouse, compared to the human protein, this gene product has a reduced tendency to form amyloid fibrils. In humans, this protein binds beta-amyloid preventing its aggregation and providing a neuroprotective role in Alzheimer's disease.

Synonyms

Transthyretin; ATTR; Prealbumin; TBPA; TTR; PALB

Gene Name

TTR

Gene ID

7276

UniProt

P02766

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human Prealbumin recombinant protein (Position: G21-E147) . Human Prealbumin shares 81% and 83.3% amino acid (aa) sequence identity with mouse and rat Prealbumin, respectively.

Clonality

Polyclonal

Tissue Specificity

Detected in serum and cerebrospinal fluid (at protein level) . Highly expressed in choroid plexus epithelial cells. Detected in retina pigment epithelium and liver. .

Applications

Flow Cytometry

Field of Research

Alzheimer's Disease, Cardiovascular, Neurodegenerative Disease, Neurology Process, Neuroscience, Serum Proteins

Purification

Immunogen affinity purified.

Form

Liquid

Function

Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. .

References & Citations

1. Benson, M. D., Dwulet, F. E. Identification of carriers of a variant plasma prealbumin (transthyretin) associated with familial amyloidotic polyneuropathy type I. J. Clin. Invest. 75: 71-75, 1985. 2. Sparkes, R. S., Sasaki, H., Mohandas, T., Yoshioka, K., Klisak, I., Sakaki, Y., Heinzmann, C., Simon, M. I. Assignment of the prealbumin (PALB) gene (familial amyloidotic polyneuropathy) to human chromosome region 18q11.2-q12.1. Hum. Genet. 75: 151-154, 1987.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

15887 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Transthyretin

Subcellular Location

Secreted. Cytoplasm.

Protein Name

Transthyretin

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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