Anti-Neuroserpin/SERPINI1 Antibody Picoband®

Neuroserpin is a protein that in humans is encoded by the SERPINI1 gene. This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified.

A synthetic peptide corresponding to a sequence at the C-terminus of human Neuroserpin, different from the related mouse sequence by two amino acids, and from the related rat sequence by three amino acids.

Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator.

1. Entrez Gene: SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1. 2. Yepes M, Lawrence DA (2004) . Neuroserpin: a selective inhibitor of tissue-type plasminogen activator in the central nervous system.. Thromb. Haemost. 91 (3) : 457–64.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.