Anti-Pax2 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Paired box gene 2, also known as PAX2, is a protein which in humans is encoded by the PAX2 gene. This gene is mapped to 10q24. PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor suppressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants.
Synonyms
Paired box protein Pax-2; PAX2
Gene Name
PAX2
Gene ID
5076
UniProt
Q02962
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Pax2, identical to the related mouse sequence.
Clonality
Polyclonal
Tissue Specificity
Expressed in primitive cells of the kidney, ureter, eye, ear and central nervous system.
Applications
Flow Cytometry
Field of Research
Cell Type Marker, Developmental Biology, Developmental Families, Domain Families, Epigenetics and Nuclear Signaling, Neuroscience, Organogenesis, Transcription, Transcription Factors
Purification
Immunogen affinity purified.
Form
Liquid
Function
Transcription factor that may have a role in kidney cell differentiation (PubMed:24676634) . Has a critical role in the development of the urogenital tract, the eyes, and the CNS. .
References & Citations
1. Entrez Gene: PAX2 paired box gene 2. 2. Pilz AJ, Povey S, Gruss P, Abbott CM (1993) . Mapping of the human homologs of the murine paired-box-containing genes. Mamm. Genome 4 (2) : 78–82. 3. Pfeffer, Peter L.; Bernhard Payter; Gerlinde Reim; Marina Pasca di Magliano; Meinrad Busslinger (2001) . The activation and maintenance of Pax2 expression at the mid-hindbrain boundary is controlled by separate enhancers. Development (133) : 307–318.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
44706 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Paired box protein Pax-2
Subcellular Location
Nucleus.
Protein Name
Paired box protein Pax-2
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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