GANT 61

GANT 61 is an inhibitor of Gli1 and Gli2 targeting the Hedgehog/GLI pathway.

Product Specifications

CAS Number

[500579-04-4]

Product Name Alternative

NSC 136476

UNSPSC

12352005

Hazard Statement

H302, H319

Target

Autophagy; Gli

Type

Reference compound

Related Pathways

Autophagy; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/GANT-61.html

Purity

99.80

Solubility

DMSO : 25 mg/mL (ultrasonic) |Ethanol : 66.67 mg/mL (ultrasonic)

Smiles

CN(C)C1=CC=CC=C1CN2C(C3=CC=NC=C3)N(CC4=CC=CC=C4N(C)C)CCC2

Molecular Formula

C27H35N5

Molecular Weight

429.60

Precautions

H302, H319

References & Citations

[1]Mazumdar T, et al. Hedgehog signaling drives cellular survival in human colon carcinoma cells. Cancer Res. 2011 Feb 1;71 (3) :1092-102.|[2]Fu J, et al. GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft. Cancer Lett. 2013 Mar 1;330 (1) :22-32.|[3]Wickstrom M, et al. Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo. Int J Cancer. 2013 Apr 1;132 (7) :1516-24.