GANT 61
GANT 61 is an inhibitor of Gli1 and Gli2 targeting the Hedgehog/GLI pathway.
Product Specifications
CAS Number
500579-04-4
Product Name Alternative
NSC 136476
UNSPSC
12352005
Hazard Statement
H302, H319
Target
Autophagy; Gli
Type
Reference compound
Related Pathways
Autophagy; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/GANT-61.html
Purity
99.80
Solubility
DMSO : 25 mg/mL (ultrasonic) |Ethanol : 66.67 mg/mL (ultrasonic)
Smiles
CN(C)C1=CC=CC=C1CN2C(C3=CC=NC=C3)N(CC4=CC=CC=C4N(C)C)CCC2
Molecular Formula
C27H35N5
Molecular Weight
429.60
Precautions
H302, H319
References & Citations
[1]Mazumdar T, et al. Hedgehog signaling drives cellular survival in human colon carcinoma cells. Cancer Res. 2011 Feb 1;71 (3) :1092-102.|[2]Fu J, et al. GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft. Cancer Lett. 2013 Mar 1;330 (1) :22-32.|[3]Wickstrom M, et al. Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo. Int J Cancer. 2013 Apr 1;132 (7) :1516-24.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC041058-500 1x 500 µL
Human Papillomavirus 16 (HPV-16) (HPV16/1058), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
TRC-KIT6375-1X1ML 1 mL
6-Beta-Naloxol Hydrochloride (1.0mg/ml in Acetonitrile)
Sign In for Pricing
View Details ![UBE2T Recombinant Rabbit Monoclonal Antibody [JE65-79]](https://cdn.genprice.uk/products/992/68dd1c8c061270361ea81dc1/imageurl/ha721385.webp)
HA721385 100 µL
UBE2T Recombinant Rabbit Monoclonal Antibody [JE65-79]
Sign In for Pricing
View Details 