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Anti-OPA1 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Dynamin-like 120 kDa protein, mitochondrial is a protein that in humans is encoded by the OPA1 gene. It is mapped to 3q29. This protein regulates mitochondrial fusion and cristae structure in the inner mitochondrial membrane (IMM) and contributes to ATP synthesis and apoptosis. This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for this gene.

Synonyms

Dynamin-like 120 kDa protein, mitochondrial;3.6.5.5; Optic atrophy protein 1; Dynamin-like 120 kDa protein, form S1; OPA1; KIAA0567

Gene Name

OPA1

Gene ID

4976

UniProt

O60313

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human OPA1, different from the related mouse and rat sequences by one amino acid.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in retina. Also expressed in brain, testis, heart and skeletal muscle. Isoform 1 expressed in retina, skeletal muscle, heart, lung, ovary, colon, thyroid gland, leukocytes and fetal brain. Isoform 2 expressed in colon, liver, kidney, thyroid gland and leukocytes. Low levels of all isoforms expressed in a variety of tissues. .

Applications

Flow Cytometry

Field of Research

Cardiovascular, Metabolism, Mitochondrial Metabolism, Neurodegenerative Disease, Neurology Process, Neuroscience, Pathways and Processes, Sensory System, Visual System

Purification

Immunogen affinity purified.

Form

Liquid

Function

Dynamin-related GTPase required for mitochondrial fusion and regulation of apoptosis. May form a diffusion barrier for proteins stored in mitochondrial cristae. Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space. May also play a role in mitochondrial genome maintenance. .

References & Citations

1. Patten DA, Wong J, Khacho M, Soubannier V, Mailloux RJ, Pilon-Larose K, MacLaurin JG, Park DS, McBride HM, Trinkle-Mulcahy L, Harper ME, Germain M, Slack RS (Nov 2014) . OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand. The EMBO Journal 33 (22) : 2676–91. 2. Santarelli R, Rossi R, Scimemi P, Cama E, Valentino ML, La Morgia C, Caporali L, Liguori R, Magnavita V, Monteleone A, Biscaro A, Arslan E, Carelli V (Mar 2015) . OPA1-related auditory neuropathy: site of lesion and outcome of cochlear implantation. Brain 138 (Pt 3) : 563–76.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

111631 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Dynamin-like 120 kDa protein, mitochondrial

Subcellular Location

Mitochondrion inner membrane ; Single-pass membrane protein . Mitochondrion intermembrane space .

Protein Name

Dynamin-like 120 kDa protein, mitochondrial

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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