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Anti-Microsomal Glutathione S-transferase 1/MGST1 Antibody Picoband® Fluoro488 Conjugated

Selected Variant

PB9723-Fluoro488

Size: 100 µg/Vial

Product Specifications

Background

Microsomal glutathione S-transferase 1 is an enzyme that in humans is encoded by the MGST1 gene. The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene.

Synonyms

Microsomal glutathione S-transferase 1; Microsomal GST-1;2.5.1.18; Microsomal GST-I; MGST1; GST12, MGST

Gene Name

MGST1

Gene ID

4257

UniProt

P10620

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human MGST1, different from the related mouse sequence by six amino acids, and from the related rat sequence by five amino acids.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in liver.

Applications

Flow Cytometry

Field of Research

Cell Biology, Developmental Biology, Metabolism, Oxidative Stress, Pathways and Processes, Redox Metabolism

Purification

Immunogen affinity purified.

Form

Liquid

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity.

References & Citations

1. Lee SH, DeJong J (1999) . Microsomal GST-I: genomic organization, expression, and alternative splicing of the human gene.. Biochim. Biophys. Acta 1446 (3) : 389–96. 2. Entrez Gene: MGST1 microsomal glutathione S-transferase 1.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

10, 18 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Microsomal glutathione S-transferase 1

Subcellular Location

Microsome . Mitochondrion outer membrane ; Peripheral membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein .

Protein Name

Microsomal glutathione S-transferase 1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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