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Anti-p90 Autoantigen/KIAA1524 CIP2A Antibody Picoband® Fluoro488 Conjugated

Selected Variant

PB9714-Fluoro488

Size: 100 µg/Vial

Product Specifications

Background

Protein CIP2A, also known as  cancerous inhibitor of PP2A  (CIP2A), is a  protein  that in humans is encoded by the  KIAA1524  gene. CIP2A is required for the malignant cellular growth and for in vivo tumor formation. In accordance with the oncogenic role of CIP2A, overexpression of CIP2A promotes Ras-elicited cell growth and transforms immortalized human cells (HEK-TERVs) . More recently CIP2A has been shown to regulate phosphorylation and activity of many other oncoproteins and to drive malignant cell growth and tumorigenesis in various human cancer types. Importantly, CIP2A deficient mice are viable, suggesting that targeting of oncogenic function of CIP2A would not result in serious side-effects.

Synonyms

Protein CIP2A; Cancerous inhibitor of PP2A; p90 autoantigen; KIAA1524; CIP2A

Gene Name

CIP2A

Gene ID

57650

UniProt

Q8TCG1

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human KIAA1524, different from the related mouse sequence by three amino acids.

Clonality

Polyclonal

Tissue Specificity

Expressed at low levels in most of the tissues. Overexpressed in head-and-neck squamous cell carcinomas (HNSCC) . Present in liver cancer cells (at protein level) . .

Applications

Flow Cytometry

Field of Research

Cancer, Oncoproteins, Oncoproteins/Suppressors, Tumor Biomarkers

Purification

Immunogen affinity purified.

Form

Liquid

Function

Oncoprotein that inhibits PP2A and stabilizes MYC in human malignancies. Promotes anchorage-independent cell growth and tumor formation. .

References & Citations

1. Dong QZ, Wang Y, Dong XJ, Li ZX, Tang ZP, Cui QZ, Wang EH (September 2010) . CIP2A is Overexpressed in Non-Small Cell Lung Cancer and Correlates with Poor Prognosis. Ann Surg Oncol 18 (3) : 857–865. 2. Junttila MR, Puustinen P, Niemelä M, et al. (2007) . CIP2A inhibits PP2A in human malignancies. Cell 130 (1) : 51–62. 3. Khanna A, Böckelman C, Hemmes A, Junttila MR, Wiksten JP, Lundin M, Junnila S, Murphy DJ, Evan GI, Haglund C, Westermarck J, Ristimäki A (June 2009) . MYC-dependent regulation and prognostic role of CIP2A in gastric cancer. J. Natl. Cancer Inst. 101 (11) : 793–805.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

102185 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Protein CIP2A

Subcellular Location

Membrane ; Single-pass membrane protein . Cytoplasm . Slightly concentrates in the perinuclear region.

Protein Name

Protein CIP2A

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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