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Anti-Involucrin/IVL Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Involucrin?is a?protein?component of human skin and in humans is encoded by the?IVL?gene. It is a highly reactive, soluble, ?transglutaminase?substrate?protein?present in?keratinocytes?of?epidermisand other?stratified squamous epithelia. It first appears in the?cell?cytosol, but ultimately becomes cross-linked to?membrane proteins?by transglutaminase thus helping in the formation of an insoluble envelope beneath theplasma membrane?functioning as a?glutamyl?donor during assembly of the cornified envelope. Additionally, Involucrin is synthesised in the?stratum spinosum?and cross linked in the?stratum granulosum?by thetransglutaminase?enzyme that makes it highly stable. Thus it provides structural support to the cell, thereby allowing the cell to resist invasion by micro-organisms.

Synonyms

Involucrin; IVL

Gene Name

IVL

Gene ID

3713

UniProt

P07476

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Involucrin.

Clonality

Polyclonal

Tissue Specificity

Keratinocytes of epidermis and other stratified squamous epithelia.

Applications

Flow Cytometry

Field of Research

Cancer, Cytoskeleton/ECM, Extracellular Matrix, Keratin, Signal Transduction, Structures, Tumor Biomarkers

Purification

Immunogen affinity purified.

Form

Liquid

Function

Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.

References & Citations

1. Djian P, Phillips M, Easley K, Huang E, Simon M, Rice RH, Green H (November 1993) . The involucrin genes of the mouse and the rat: study of their shared repeats. Mol. Biol. Evol. 10 (6) : 1136–49. 2. Eckert RL, Green H (Sep 1986) . Structure and evolution of the human involucrin gene. Cell 46 (4) : 583–9. 3. Green H, Djian P (November 1992) . Consecutive actions of different gene-altering mechanisms in the evolution of involucrin. Mol. Biol. Evol. 9 (6) : 977–1017.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

68479 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Involucrin

Subcellular Location

Cytoplasm. Constituent of the scaffolding of the cornified envelope.

Protein Name

Involucrin

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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