What sizes are available for Anti-GRK6 Antibody Picoband® Fluoro647 Conjugated?

Anti-GRK6 Antibody Picoband® Fluoro647 Conjugated is available in the following size(s): 100 µg/Vial.

Is Anti-GRK6 Antibody Picoband® Fluoro647 Conjugated in stock?

Anti-GRK6 Antibody Picoband® Fluoro647 Conjugated is currently made to order / not held in immediate stock. Contact us for lead time.

What dilution range is recommended for immunohistochemistry (IHC) with this antibody?

A starting IHC dilution range is listed on the datasheet, but should be optimized for your specific tissue type and staining protocol.

Can I request a Safety Data Sheet (SDS) for this product?

Yes, safety data sheets are available for hazardous or chemically classified products and can be provided on request or downloaded from the product page.

Can this product be used for co-immunoprecipitation (Co-IP)?

Suitability for Co-IP depends on the specific antibody and is noted under validated applications on the datasheet. If it isn’t listed, contact our technical support team for guidance based on your target and sample type.

Anti-GRK6 Antibody Picoband® Fluoro647 Conjugated

Q: What is the catalog number for Anti-GRK6 Antibody Picoband® Fluoro647 Conjugated?

The catalog number for Anti-GRK6 Antibody Picoband® Fluoro647 Conjugated is PB9709-Fluoro647.

Product Specifications

Background

G protein-coupled receptor kinase 6?is an?enzyme?that in humans is encoded by the?GRK6?gene. It is mapped to 5q35. This gene encodes a member of the guanine nucleotide-binding protein (G protein) -coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. Also, GRK6 appears to be involved in responses to?morphine.

Synonyms

G protein-coupled receptor kinase 6;2.7.11.16; G protein-coupled receptor kinase GRK6; GRK6; GPRK6

Gene Name

GRK6

Gene ID

2870

UniProt

P43250

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human GRK6, different from the related mouse sequence by four amino acids, and from the related rat sequence by three amino acids.

Clonality

Polyclonal

Tissue Specificity

Widely expressed. .

Applications

Flow Cytometry

Field of Research

Cardiovascular, G Protein Signaling, Hypertrophy, Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction, Signaling Pathway

Purification

Immunogen affinity purified.

Form

Liquid

Function

Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity) . Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro) . .

References & Citations

1. Entrez Gene: GRK6 G protein-coupled receptor kinase 6. 2. Haribabu B, Snyderman R (Nov 1993) . Identification of additional members of human G-protein-coupled receptor kinase multigene family. Proc Natl Acad Sci U S A 90 (20) : 9398–402. 3. Raehal KM, Schmid CL, Medvedev IO, Gainetdinov RR, Premont RT, Bohn LM (June 2009) . Morphine-Induced Physiological and Behavioral Responses in Mice Lacking G Protein-Coupled Receptor Kinase 6. Drug and Alcohol Dependence 104 (3) : 187–96.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

65991 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

Gene Name Synonym

G protein-coupled receptor kinase 6

Subcellular Location

Membrane; Lipid-anchor.

Protein Name

G protein-coupled receptor kinase 6

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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