Anti-IP10/CXCL10 Antibody Picoband® Fluoro647 Conjugated

C-X-C motif chemokine 10 (CXCL10), also known as Interferon gamma-induced protein 10 kDa (IP-10) or small-inducible cytokine B10, is a protein that in humans is encoded by the CXCL10 gene. It is a small cytokine belonging to the CXC chemokine family. The gene for CXCL10 is located on human chromosome 4 in a cluster among several other CXC chemokines. Luster et al. (1987) reported the isolation of an interferon-inducible gene that encodes a 98-amino acid protein called IP10. The chemokine IFN-gamma-inducible protein 10 (IP-10; CXCL10), a CXC chemokine, and its receptor, CXCR3, were found to be overexpressed in lymph node cells of EAMG rats. IP10 inhibits bone marrow colony formation, has antitumor activity in vivo, is a chemoattractant for human monocytes and T cells, and promotes T cell adhesion to endothelial cells.

C-X-C motif chemokine 10;10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10; Small-inducible cytokine B10; CXCL10 (1-73) ; CXCL10; INP10, SCYB10

E. coli-derived human IP10 recombinant protein (Position: V22-P98) . Human IP10 shares 70.1% and 72.7% amino acid (aa) sequence identity with mouse and rat IP10, respectively.

1. Feferman, T., Maiti, P. K., Berrih-Aknin, S., Bismuth, J., Bidault, J., Fuchs, S., Souroujon, M. C.Overexpression of IFN-induced protein 10 and its receptor CXCR3 in myasthenia gravis.J. Immun.174: 5324-5331, 2005. 2. Luster AD, Unkeless JC, Ravetch JV (1985) . Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins. Nature 315 (6021) : 672–6. 3. Luster AD, Jhanwar SC, Chaganti RS, Kersey JH, Ravetch JV (May 1987) . Interferon-inducible gene maps to a chromosomal band associated with a (4;11) translocation in acute leukemia cells. Proc. Natl. Acad. Sci. U.S.A. 84 (9) : 2868–71.