Anti-BMP6 Antibody Picoband® Fluoro488 Conjugated

Bone morphogenetic protein 6?is a?protein?that in humans is encoded by the?BMP6?gene. It is mapped to 6p24-p23. The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity.

A synthetic peptide corresponding to a sequence at the C-terminus of human BMP6, different from the related mouse sequence by six amino acids, and from the related rat sequence by three amino acids.

Cell Biology, Cell Cycle, Cell Differentiation, Cytoskeleton/ECM, Extracellular Matrix, Growth Factors/Hormones, Secreted, Signal Transduction, Signaling Pathways, Stem Cells, Structures, TGF Beta

1. Entrez Gene: BMP6 bone morphogenetic protein 6. 2. Hahn GV, Cohen RB, Wozney JM, Levitz CL, Shore EM, Zasloff MA, Kaplan FS (Dec 1992) . A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7. Genomics 14 (3) : 759–62. 3. Sauermann U, Meyermann R, Schluesener HJ (Jan 1993) . Cloning of a novel TGF-beta related cytokine, the vgr, from rat brain: cloning of and comparison to homologous human cytokines. J Neurosci Res 33 (1) : 142–7.