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Anti-MAPK6 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Mitogen-activated protein kinase 6 is an enzyme that in humans is encoded by the MAPK6 gene. It is mapped to 15q21. The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases) . MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblastsupon treatment with serum or phorbol esters.

Synonyms

Mitogen-activated protein kinase 6; MAP kinase 6; MAPK 6;2.7.11.24; Extracellular signal-regulated kinase 3; ERK-3; MAP kinase isoform p97; p97-MAPK; MAPK6; ERK3, PRKM6

Gene Name

MAPK6

Gene ID

5597

UniProt

Q16659

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human MAPK6 recombinant protein (Position: E520-N721) . Human MAPK6 shares 86.2% and 82.8% amino acid (aa) sequence identity with mouse and rat MAPK6, respectively.

Clonality

Polyclonal

Tissue Specificity

Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts.

Applications

Flow Cytometry

Field of Research

Cytoplasmic, MAPK Pathway, Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction, Signaling Pathways, Stem Cells, TGF Beta

Purification

Immunogen affinity purified.

Form

Liquid

Function

Atypical MAPK protein. Phosphorylates microtubule- associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity) . .

References & Citations

1. Entrez Gene: MAPK6 mitogen-activated protein kinase 6. 2. Cheng M, Boulton TG, Cobb MH (1996) . ERK3 is a constitutively nuclear protein kinase. J. Biol. Chem.271 (15) : 8951–8958. 3. Meloche S, Beatty BG, Pellerin J (Dec 1996) . Primary structure, expression and chromosomal locus of a human homolog of rat ERK3. Oncogene 13 (7) : 1575–9.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

82681 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Mitogen-activated protein kinase 6

Subcellular Location

Cytoplasm . Nucleus . Translocates to the cytoplasm following interaction with MAPKAPK5. .

Protein Name

Mitogen-activated protein kinase 6

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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