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Anti-Lysozyme/LYZ Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

In humans, the lysozyme enzyme is encoded by the LYZ gene. This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta [1-4] glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine) . Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis.

Synonyms

Lysozyme C;3.2.1.17;1,4-beta-N-acetylmuramidase C; LYZ; LZM

Gene Name

LYZ

Gene ID

4069

UniProt

P61626

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Lysozyme.

Clonality

Polyclonal

Tissue Specificity

Cornea and other tissues.

Applications

Flow Cytometry

Field of Research

Cell Biology, Immunology, Innate Immunity, Macrophage/Inflammation, Organelles, Subcellular Markers, Tags & Cell Markers

Purification

Immunogen affinity purified.

Form

Liquid

Function

Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte- macrophage system and enhance the activity of immunoagents.

References & Citations

1. McKenzie HA, White FH (1991) . Lysozyme and alpha-lactalbumin: structure, function, and interrelationships. Adv. Protein Chem. 41: 173–315. 2. Peters CW, Kruse U, Pollwein R, Grzeschik KH, Sippel AE (July 1989) . The human lysozyme gene. Sequence organization and chromosomal localization. Eur. J. Biochem. 182 (3) : 507–16. 3. Yoshimura K, Toibana A, Nakahama K (January 1988) . Human lysozyme: sequencing of a cDNA, and expression and secretion by Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun. 150 (2) : 794–801.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

16537 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Lysozyme C

Subcellular Location

Secreted.

Protein Name

Lysozyme C

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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