Anti-LIFR Antibody Picoband® Fluoro647 Conjugated

LIFR also known as CD118 (Cluster of Differentiation 118), is a subunit of a receptor for leukemia inhibitory factor. This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t (5;8) (p13; q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene.

Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.

1. Entrez Gene: LIFR leukemia inhibitory factor receptor alpha. 2. Lass A, Weiser W, Munafo A, Loumaye E (2002) . Leukemia inhibitory factor in human reproduction. Fertil. Steril. 76 (6) : 1091–6. 3. Tomida M (2003) . Structural and functional studies on the leukemia inhibitory factor receptor (LIF-R) : gene and soluble form of LIF-R, and cytoplasmic domain of LIF-R required for differentiation and growth arrest of myeloid leukemic cells.. Leuk. Lymphoma 37 (5–6) : 517–25.