Anti-Galectin 8/LGALS8 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Galectin-8 is a protein of the galectin family that in humans is encoded by the LGALS8 gene. This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified.

Synonyms

Galectin-8; Gal-8; Po66 carbohydrate-binding protein; Po66-CBP; Prostate carcinoma tumor antigen 1; PCTA-1; LGALS8

Gene Name

LGALS8

Gene ID

3964

UniProt

O00214

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Galectin 8, different from the related mouse and rat sequences by six amino acids.

Clonality

Polyclonal

Tissue Specificity

Ubiquitous. Selective expression by prostate carcinomas versus normal prostate and benign prostatic hypertrophy.

Applications

Flow Cytometry

Field of Research

Cancer, Cell Adhesion, Invasion/Microenvironment, Tumor Immunology, Tumor-Associated Antigens

Purification

Immunogen affinity purified.

Form

Liquid

Function

Lectin with a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans. .

References & Citations

1. Entrez Gene: LGALS8 lectin, galactoside-binding, soluble, 8 (galectin 8) . 2. Hadari YR, Paz K, Dekel R, Mestrovic T, Accili D, Zick Y (Mar 1995) . Galectin-8. A new rat lectin, related to galectin-4. J Biol Chem 270 (7) : 3447–53. 3. Su ZZ, Lin J, Shen R, Fisher PE, Goldstein NI, Fisher PB (Aug 1996) . Surface-epitope masking and expression cloning identifies the human prostate carcinoma tumor antigen gene PCTA-1 a member of the galectin gene family. Proc Natl Acad Sci U S A 93 (14) : 7252–7.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

35808 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

Gene Name Synonym

Galectin-8

Subcellular Location

Cytoplasm .

Protein Name

Galectin-8

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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Anti-Galectin 8/LGALS8 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Synonyms

Gene Name

Gene ID

UniProt

Host

Reactivity

Cross Reactivity

Immunogen

Clonality

Tissue Specificity

Applications

Field of Research

Purification

Form

Function

References & Citations

Storage Conditions

Calculated Molecular Weight

Specificity

Applications Notes

Gene Name Synonym

Subcellular Location

Protein Name

Isotype

Contents

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