Anti-ING1 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Inhibitor of growth protein 1 is a protein that in humans is encoded by the ING1 gene. It is mapped to 13q34. This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
Synonyms
Inhibitor of growth protein 1; ING1
Gene Name
ING1
Gene ID
3621
UniProt
Q9UK53
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human ING1, different from the related mouse sequence by seven amino acids.
Clonality
Polyclonal
Tissue Specificity
Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines. .
Applications
Flow Cytometry
Field of Research
Acetylation, Apoptosis, Cancer, Cancer Susceptibility, Cell Biology, Chromatin Modifying Enzymes, Epigenetics and Nuclear Signaling, Intracellular, Oncoproteins/Suppressors, p53 Pathway, Transcription, Tumor Suppressors
Purification
Immunogen affinity purified.
Form
Liquid
Function
Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene. .
References & Citations
1. Entrez Gene: ING1 inhibitor of growth family, member 1. 2. Garkavtsev I, Kazarov A, Gudkov A, Riabowol K (Jan 1997) . Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation. Nat Genet 14 (4) : 415–20. 3. Garkavtsev I, Demetrick D, Riabowol K (Jul 1997) . Cellular localization and chromosome mapping of a novel candidate tumor suppressor gene (ING1) . Cytogenet Cell Genet 76 (3-4) : 176–8.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
46738 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Inhibitor of growth protein 1
Subcellular Location
Nucleus .
Sequence Similarities
Contains 1 HMG box DNA-binding domain.
Protein Name
Inhibitor of growth protein 1
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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