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Anti-HSF4 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Heat shock factor protein 4 is a protein that in humans is encoded by the HSF4 gene. It is mapped to 16q21. Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described.

Synonyms

Heat shock factor protein 4; HSF 4; hHSF4; Heat shock transcription factor 4; HSTF 4; HSF4

Gene Name

HSF4

Gene ID

3299

UniProt

Q9ULV5

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human HSF4, different from the related mouse sequence by two amino acids.

Clonality

Polyclonal

Tissue Specificity

Expressed in heart, skeletal muscle, eye and brain, and at much lower levels in some other tissues. .

Applications

Flow Cytometry

Field of Research

Chromatin Binding Proteins, DNA/RNA Binding, Epigenetics and Nuclear Signaling, Transcription, Transcription Factors

Purification

Immunogen affinity purified.

Form

Liquid

Function

DNA-binding protein that specifically binds heat shock promoter elements (HSE) . Isoform HSF4A represses transcription while the isoform HSF4B activates transcription. .

References & Citations

1. Bu L, Jin Y, Shi Y, Chu R, Ban A, Eiberg H, Andres L, Jiang H, Zheng G, Qian M, Cui B, Xia Y, Liu J, Hu L, Zhao G, Hayden MR, Kong X (Jun 2002) . Mutant DNA-binding domain of HSF4 is associated with autosomal dominant lamellar and Marner cataract. Nat Genet 31 (3) : 276–8. 2. Nakai A, Tanabe M, Kawazoe Y, Inazawa J, Morimoto RI, Nagata K (Jan 1997) . HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator. Mol Cell Biol 17 (1) : 469–81. 3. Tanabe M, Sasai N, Nagata K, Liu XD, Liu PC, Thiele DJ, Nakai A (Nov 1999) . The mammalian HSF4 gene generates both an activator and a repressor of heat shock genes by alternative splicing. J Biol Chem 274 (39) : 27845–56.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

53011 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Heat shock factor protein 4

Subcellular Location

Nucleus.

Sequence Similarities

Contains 1 HMG box DNA-binding domain.

Protein Name

Heat shock factor protein 4

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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