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Anti-HMG4/HMGB3 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

High-mobility group protein B, also known as HMG4, is a protein that in humans is encoded by the HMGB3 gene. This gene encodes a member of a family of proteins containing one or more high mobility group DNA-binding motifs. The encoded protein plays an important role in maintaining stem cell populations, and may be aberrantly expressed in tumor cells. A mutation in this gene was associated with microphthalmia, syndromic 13. There are numerous pseudogenes of this gene on multiple chromosomes. Alternative splicing results in multiple transcript variants.

Synonyms

High mobility group protein B3; High mobility group protein 2a; HMG-2a; High mobility group protein 4; HMG-4; HMGB3; HMG2A, HMG4

Gene Name

HMGB3

Gene ID

3149

UniProt

O15347

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human HMG4, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Tissue Specificity

Expressed predominantly in placenta.

Applications

Flow Cytometry

Field of Research

Chromatin Binding Proteins, Chromosome Structure, DNA/RNA Binding, Epigenetics and Nuclear Signaling

Purification

Immunogen affinity purified.

Form

Liquid

Function

Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non- canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity) . Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor (By similarity) . Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling (By similarity) . .

References & Citations

1. Entrez Gene: HMGB3 high-mobility group box 3. 2. Davis DL, Burch JB (1992) . Isolation of a chicken HMG2 cDNA clone and evidence for an HMG2-specific 3'-untranslated region.. Gene 113 (2) : 251–6. 3. Vaccari T, Beltrame M, Ferrari S, Bianchi ME (Aug 1998) . Hmg4, a new member of the Hmg1/2 gene family.Genomics 49 (2) : 247–52.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

22980 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

High mobility group protein B3

Subcellular Location

Nucleus . Chromosome . Cytoplasm .

Sequence Similarities

Contains 1 HMG box DNA-binding domain.

Protein Name

High mobility group protein B3

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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