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Anti-PTOV1 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Prostate tumor overexpressed gene 1 protein is a protein that in humans is encoded by the PTOV1 gene. It is mapped to 19q13.33. This gene encodes a protein that was found to be overexpressed in prostate adenocarcinomas. The encoded protein was found to interact with the lipid raft protein flotillin-1 and shuttle it from the cytoplasm to the nucleus in a cell cycle dependent manner. Alternative splicing of this gene results in multiple transcript variants.

Synonyms

Prostate tumor-overexpressed gene 1 protein; PTOV-1; Activator interaction domain-containing protein 2; PTOV1; ACID2; PP642, UNQ6127/PRO20092

Gene Name

PTOV1

Gene ID

53635

UniProt

Q86YD1

Host

Rabbit

Reactivity

Human, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human PTOV1, different from the related mouse and rat sequences by one amino acid.

Clonality

Polyclonal

Tissue Specificity

Expressed in brain, heart, kidney, liver, placenta, skeletal muscle and small intestine. .

Applications

Flow Cytometry

Field of Research

Cancer, Cell Cycle, Cell Division, Epigenetics and Nuclear Signaling, Transcription, Transcription Factors, Tumor Antigens, Tumor Biomarkers

Purification

Immunogen affinity purified.

Form

Liquid

Function

May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation. .

References & Citations

1. Entrez Gene: PTOV1 prostate tumor overexpressed gene 1. 2. Santamaria A, Castellanos E, Gomez V, Benedit P, Renau-Piqueras J, Morote J, Reventos J, Thomson TM, Paciucci R (Feb 2005) . PTOV1 enables the nuclear translocation and mitogenic activity of flotillin-1, a major protein of lipid rafts. Mol Cell Biol 25 (5) : 1900–11. 3. Santamaria A, Fernandez PL, Farre X, Benedit P, Reventos J, Morote J, Paciucci R, Thomson TM (Feb 2003) .PTOV-1, a novel protein overexpressed in prostate cancer, shuttles between the cytoplasm and the nucleus and promotes entry into the S phase of the cell division cycle. Am J Pathol 162 (3) : 897–905.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=RP1087-Fluoro488

Calculated Molecular Weight

46869 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Prostate tumor-overexpressed gene 1 protein

Subcellular Location

Cell membrane. Cytoplasm, perinuclear region. Nucleus. Translocates from the cytoplasm to the nucleus at the onset of S-phase. Also localizes to lipid rafts.

Sequence Similarities

Belongs to the Mediator complex subunit 25 family. PTOV1 subfamily.

Protein Name

Prostate tumor-overexpressed gene 1 protein

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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