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Anti-Fos B/FOSB Antibody Picoband® Fluoro488 Conjugated

Selected Variant

RP1086-Fluoro488

Size: 100 µg/Vial

Product Specifications

Background

FOSL1

Synonyms

Protein fosB; G0/G1 switch regulatory protein 3; FOSB; G0S3

Gene Name

FOSB

Gene ID

2354

UniProt

P53539

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Fos B, different from the related mouse sequence by two amino acids.

Clonality

Polyclonal

Tissue Specificity

Testis-specific. Expressed in prostate cancer (at protein level) . .

Applications

Flow Cytometry

Field of Research

Cancer, Cancer Metabolism, Cardiovascular, Fatty Acid Oxidation, Fatty Acids, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Lipids/Lipoproteins, Mesenchymal Stem Cells, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism of Lipids and Lipoproteins, Pathways and Processes, Redox Metabolism, Signal Transduction, Stem Cells

Purification

Immunogen affinity purified.

Form

Liquid

Function

FosB interacts with Jun proteins enhancing their DNA binding activity.

References & Citations

1. Kelz, M. B., Chen, J., Carlezon, W. A., Jr., Whisler, K., Gilden, L., Beckmann, A. M., Steffen, C., Zhang, Y.-J., Marotti, L., Self, D. W., Tkatch, T., Baranauskas, G., Surmeier, D. J., Neve, R. L., Duman, R. S., Picciotto, M. R., Nestler, E. J.Expression of the transcription factor delta-FosB in the brain controls sensitivity to cocaine.Nature 401: 272-276, 1999. 2. Martin-Gallardo, A., McCombie, W. R., Gocayne, J. D., FitzGerald, M. G., Wallace, S., Lee, B. M. B., Lamerdin, J., Trapp, S., Kelley, J. M., Liu, L.-I., Dubnick, M., Johnston-Dow, L. A., Kerlavage, A. R., de Jong, P., Carrano, A., Fields, C., Venter, J. C.Automated DNA sequencing and analysis of 106 kilobases from human chromosome 19q13.3.Nature Genet. 1: 34-39, 1992. 3. Nakabeppu, Y., Nathans, D.A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity.Cell 64: 751-759, 1991.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

35928 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Protein fosB

Subcellular Location

Nucleus.

Sequence Similarities

Belongs to the bZIP family. Fos subfamily.

Protein Name

Protein fosB

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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