Anti-Wnt3 Antibody Picoband® Fluoro488 Conjugated

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region.

Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube (By similarity) . .

1. Entrez Gene: WNT3 wingless-type MMTV integration site family, member 3. 2. Liu P, Wakamiya M, Shea MJ et al. (1999) . Requirement for Wnt3 in vertebrate axis formation.Nat. Genet. 22 (4) : 361–5. 3. Roelink H, Wang J, Black DM, Solomon E, Nusse R (Dec 1993) . Molecular cloning and chromosomal localization to 17q21 of the human WNT3 gene. Genomics 17 (3) : 790–2.