Anti-Surfactant protein D/SFTPD Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Surfactant, pulmonary-associated protein D, also known as SFTPD or SP-D, is a protein which in humans is encoded by the SFTPD gene. It is mapped to 10q22.2-q23.1. The protein encoded by this gene is part of the innate immune response, protecting the lungs against inhaled microorganisms and chemicals. The encoded protein may also be involved in surfactant metabolism.

Synonyms

Pulmonary surfactant-associated protein D; PSP-D; SP-D; Collectin-7; Lung surfactant protein D; SFTPD; COLEC7, PSPD, SFTP4

Gene Name

SFTPD

Gene ID

6441

UniProt

P35247

Host

Rabbit

Reactivity

Human, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Surfactant protein D, different from the related mouse and rat sequences by eight amino acids.

Clonality

Polyclonal

Tissue Specificity

Expressed in lung, brain, pancreas and adipose tissue (mainly mature adipocytes) . .

Applications

Flow Cytometry

Field of Research

Calcium Binding Proteins, Calcium Signaling, Cancer, Cancer Metabolism, Cell Biology, Defensin, Human Protein, Immunology, Innate Immunity, Macrophage/Inflammation, Metabolism, Microbiology, Oxidative Stress, Pathways and Processes, Protein, Redox Metabolism, Signal Transduction, Signaling Pathway

Purification

Immunogen affinity purified.

Form

Liquid

Function

Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties. .

References & Citations

1. Brandt EB, Mingler MK, Stevenson MD, Wang N, Khurana Hershey GK, Whitsett JA, Rothenberg ME (May 2008) . Surfactant protein D alters allergic lung responses in mice and human subjects. J. Allergy Clin. Immunol. 121 (5) : 1140–1147.e2. 2. Lu J, Willis AC, Reid KB (June 1992) .Purification, characterization and cDNA cloning of human lung surfactant protein D. Biochem. J. 284. 284 (Pt 3) : 795–802. 3. Rust K, Grosso L, Zhang V, Chang D, Persson A, Longmore W, Cai GZ, Crouch E (October 1991) . Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain. Arch. Biochem. Biophys. 290 (1) : 116–26.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

37728 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

Gene Name Synonym

Pulmonary surfactant-associated protein D

Subcellular Location

Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film.

Sequence Similarities

Belongs to the SFTPD family.

Protein Name

Pulmonary surfactant-associated protein D

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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Anti-Surfactant protein D/SFTPD Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Synonyms

Gene Name

Gene ID

UniProt

Host

Reactivity

Cross Reactivity

Immunogen

Clonality

Tissue Specificity

Applications

Field of Research

Purification

Form

Function

References & Citations

Storage Conditions

Calculated Molecular Weight

Specificity

Applications Notes

Gene Name Synonym

Subcellular Location

Sequence Similarities

Protein Name

Isotype

Contents

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