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Anti-KIN Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

DNA/RNA-binding protein KIN17, also known as BTCD or KIN17, is a protein that in humans is encoded by the KIN gene. This gene is mapped to 10p14. The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog. Alternative splicing of this gene results in multiple transcript variants.

Synonyms

DNA/RNA-binding protein KIN17; Binding to curved DNA; KIN, antigenic determinant of recA protein homolog; KIN ; BTCD, KIN17

Gene Name

KIN

Gene ID

22944

UniProt

O60870

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human KIN recombinant protein (Position: K3-K202) . Human KIN shares 98% amino acid (aa) sequence identity with mouse KIN.

Clonality

Polyclonal

Tissue Specificity

Ubiquitously expressed in all tissues examined, with highest levels in skeletal muscle, heart and testis. Differentially expressed in non-tumorigenic and tumorigenic cell lines. Highly expressed in proliferating epithelial keratinocyte cells in vitro (at protein level) . .

Applications

Flow Cytometry

Field of Research

DNA/RNA, DNA Damage & Repair, DNA Damage Response, Epigenetics and Nuclear Signaling

Purification

Immunogen affinity purified.

Form

Liquid

Function

Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity) . Binds via its C-terminal domain to RNA in vitro. .

References & Citations

1. Kannouche, P., Mauffrey, P., Pinon-Lataillade, G., Mattei, M. G., Sarasin, A., Daya-Grosjean, L., Angulo, J. F. Molecular cloning and characterization of the human KIN17 cDNA encoding a component of the UVC response that is conserved among metazoans. Carcinogenesis 21: 1701-1710, 2000. 2. Timchenko, T., Bailone, A., Devoret, R. Btcd, a mouse protein that binds to curved DNA, can substitute in Escherichia coli for H-NS, a bacterial nucleoid protein. EMBO J. 15: 3986-3992, 1996.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

45374 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

DNA/RNA-binding protein KIN17

Subcellular Location

Nucleus . Cytoplasm . During S phase, strongly associated with the nuclear matrix, and to chromosomal DNA in the presence of DNA damage. Also shows cytoplasmic localization in elongated spermatids. .

Sequence Similarities

Belongs to the KIN17 family.

Protein Name

DNA/RNA-binding protein KIN17

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Curated Selection

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