Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-IDH2 Antibody Picoband® Fluoro550 Conjugated

Product Specifications

Background

Isocitrate dehydrogenase [NADP], mitochondrial is an enzyme that in humans is encoded by the IDH2 gene. Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD (+) as the electron acceptor and the other NADP (+) . Five isocitrate dehydrogenases have been reported: three NAD (+) -dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP (+) -dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP (+) -dependent isozyme is a homodimer. The protein encoded by this gene is the NADP (+) -dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants.

Synonyms

Isocitrate dehydrogenase [NADP], mitochondrial; IDH;1.1.1.42; ICD-M; IDP; NADP (+) -specific ICDH; Oxalosuccinate decarboxylase; IDH2

Gene Name

IDH2

Gene ID

3418

UniProt

P48735

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human IDH2, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Applications

Flow Cytometry

Field of Research

Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex.

References & Citations

1. Entrez Gene: IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial. 2. Xu X, Zhao J, Xu Z, Peng B, Huang Q, Arnold E, Ding J (Aug 2004) . Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity. The Journal of Biological Chemistry 279 (32) : 33946–57.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=PB9602-Fluoro550

Calculated Molecular Weight

45,180 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Isocitrate dehydrogenase [NADP], mitochondrial

Subcellular Location

Mitochondrion.

Sequence Similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Protein Name

Isocitrate dehydrogenase [NADP], mitochondrial

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

4-Desiodo 4-chloroiopmamidol
sc-499576 5 mg

4-Desiodo 4-chloroiopmamidol

Ask
View Details
Oxr1 Mouse Gene Knockout Kit (CRISPR)
KN512703 1 Kit

Oxr1 Mouse Gene Knockout Kit (CRISPR)

Ask
View Details
NL-W05-H Die-cut & Printed Numbers & Letters
234170 1950 Pack (78 Label (s) x 25 Card)

NL-W05-H Die-cut & Printed Numbers & Letters

Ask
View Details
HIST1H2BA, NT (HIST1H2BA, TSH2B, Histone H2B type 1-A, Histone H2B, testis, Testis-specific histone H2B) (FITC)
MBS6306783-01 0.2 mL

HIST1H2BA, NT (HIST1H2BA, TSH2B, Histone H2B type 1-A, Histone H2B, testis, Testis-specific histone H2B) (FITC)

Ask
View Details
HIST1H2BA, NT (HIST1H2BA, TSH2B, Histone H2B type 1-A, Histone H2B, testis, Testis-specific histone H2B) (FITC)
MBS6306783-02 5x 0.2 mL

HIST1H2BA, NT (HIST1H2BA, TSH2B, Histone H2B type 1-A, Histone H2B, testis, Testis-specific histone H2B) (FITC)

Ask
View Details
Rat Sacsin (SACS) ELISA Kit
MBS9921884-01 48 Well

Rat Sacsin (SACS) ELISA Kit

Ask
View Details