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Anti-FRA2/FOSL2 Antibody Picoband® Fluoro488 Conjugated

Selected Variant

PB9591-Fluoro488

Size: 100 µg/Vial

Product Specifications

Background

Fos-related antigen 2 is a protein that in humans is encoded by the FOSL2 gene. The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.

Synonyms

Fos-related antigen 2; FRA-2; FOSL2; FRA2

Gene Name

FOSL2

Gene ID

2355

UniProt

P15408

Host

Rabbit

Reactivity

Human, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human FRA2, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Tissue Specificity

Liver.

Applications

Flow Cytometry

Field of Research

Cancer Susceptibility, Domain Families, Epigenetics and Nuclear Signaling, Hlh/Leucine Zipper, Proto-Oncogenes, Transcription

Purification

Immunogen affinity purified.

Form

Liquid

Function

Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts. .

References & Citations

1. Entrez Gene: FOSL2 FOS-like antigen 2. 2. Matsui M, Tokuhara M, Konuma Y et al. (1990) . Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation.. Oncogene 5 (3) : 249–55. 3. Molven A, Houge G, Berger R (1997) . Chromosomal assignment of the human gene encoding the Fos-related antigen-2 (FRA2) to chromosome 2p22-p23.. Genomics38 (1) : 72–5.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

35193 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Fos-related antigen 2

Subcellular Location

Nucleus.

Sequence Similarities

Belongs to the bZIP family. Fos subfamily.

Protein Name

Fos-related antigen 2

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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