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Anti-FMO1 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Several transcript variants encoding different isoforms have been found for this gene.

Synonyms

Dimethylaniline monooxygenase [N-oxide-forming] 1;1.14.13.8; Dimethylaniline oxidase 1; Fetal hepatic flavin-containing monooxygenase 1; FMO 1; FMO1

Gene Name

FMO1

Gene ID

2326

UniProt

Q01740

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human FMO1, different from the related mouse sequence by one amino acid, and from the related rat sequence by two amino acids.

Clonality

Polyclonal

Tissue Specificity

Expressed mainly in fetal liver, adult kidney and, to a lesser extent, the intestine.

Applications

Flow Cytometry

Field of Research

Cancer, Cell Biology, Drug Metabolism, Metabolic Signaling Pathways, Metabolism, Oxidative Stress, Pathways and Processes, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines.

References & Citations

1. Entrez Gene: FMO1 flavin containing monooxygenase 1. 2. Cashman JR (2004) . The implications of polymorphisms in mammalian flavin-containing monooxygenases in drug discovery and development.Drug Discov. Today 9 (13) : 574–581. 3. Dolphin C, Shephard EA, Povey S et al. (1991) . Cloning, primary sequence, and chromosomal mapping of a human flavin-containing monooxygenase (FMO1) .J. Biol. Chem. 266 (19) : 12379–85.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

60 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Dimethylaniline monooxygenase [N-oxide-forming] 1

Subcellular Location

Microsome membrane. Endoplasmic reticulum membrane.

Sequence Similarities

Belongs to the FMO family.

Protein Name

Dimethylaniline monooxygenase [N-oxide-forming] 1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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